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Mevy Trisna Pengarang Mhd Riza Marjoni Pengarang Ainun Naim Pengarang

Traditional usage and many studies show that leaves salam and leaves bitter on a single use have an antidiabetic effect. Aims and Objectives: The aim of this research is to know the combination of aqueous extract of salam leaves and bitter leaves in decreasing blood glucose level in white male mice-induced alloxan using pre-test and post-test group control design. Materials and Methods: White male mice are grouped into six treatment groups: Normal control, negative controls (CMC-Na 0,5%), positive control (metformin HCl dose of 20 mg/KgBW), SB 7,5:20, SB 15:40, and SB 30:80. All groups except normal control-induced alloxan dose of 200 mg/KgBW on day-0, treatment continued from day 1–day 24. The data obtained were blood glucose level of mice before and after treatment. Blood glucose level data were analyzed using Shapiro–Wilk test and continued by analysis of variance (ANOVA) with α = 0.01. Results: The results showed that there was a decrease in blood glucose level a combination of aqueous extract salam leaves and bitter leaves at P <0.01.